Naoki Ishiguro Selected Research

Adalimumab (Humira)

2/2022	Efficacy and safety of filgotinib in combination with methotrexate in Japanese patients with active rheumatoid arthritis who have an inadequate response to methotrexate: Subpopulation analyses of 24-week data of a global phase 3 study (FINCH 1).
1/2018	High rate of improvement in serum matrix metalloproteinase-3 levels at 4 weeks predicts remission at 52 weeks in RA patients treated with adalimumab.
1/2017	Low disease activity for up to 3 years after adalimumab discontinuation in patients with early rheumatoid arthritis: 2-year results of the HOPEFUL-3 Study.
6/2016	Effect of Methotrexate Plus Adalimumab on the Achievement of Rheumatoid Arthritis Therapeutic Goals: Post Hoc Analysis of Japanese Patients (MELODY Study).
1/2016	Longterm Retention Rate and Risk Factors for Adalimumab Discontinuation Due To Efficacy and Safety in Japanese Patients with Rheumatoid Arthritis: An Observational Cohort Study.
1/2016	Adalimumab discontinuation in patients with early rheumatoid arthritis who were initially treated with methotrexate alone or in combination with adalimumab: 1 year outcomes of the HOPEFUL-2 study.
7/2015	Trend of patient characteristics and its impact on the response to adalimumab in patients with rheumatoid arthritis: post hoc time-course analysis of an all-case PMS in Japan.
5/2014	Recovery of clinical but not radiographic outcomes by the delayed addition of adalimumab to methotrexate-treated Japanese patients with early rheumatoid arthritis: 52-week results of the HOPEFUL-1 trial.
5/2014	Safety and effectiveness of adalimumab in Japanese rheumatoid arthritis patients: postmarketing surveillance report of 7740 patients.
3/2014	Adalimumab, a human anti-TNF monoclonal antibody, outcome study for the prevention of joint damage in Japanese patients with early rheumatoid arthritis: the HOPEFUL 1 study.

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Naoki Ishiguro Research Topics

Disease

115	Rheumatoid Arthritis 07/2023 - 06/2003
59	Neoplasms (Cancer) 01/2021 - 07/2002
22	Spinal Cord Diseases 01/2021 - 10/2004
20	Osteoarthritis 05/2021 - 01/2004
18	Pain (Aches) 01/2021 - 08/2004
17	Spinal Cord Injuries (Spinal Cord Injury) 01/2020 - 09/2004
16	Infections 02/2022 - 07/2005
14	Inflammation (Inflammations) 01/2024 - 08/2009
14	Neoplasm Metastasis (Metastasis) 07/2020 - 10/2005
14	Wounds and Injuries (Trauma) 07/2020 - 01/2011
11	Osteoporosis 08/2020 - 06/2005
11	Osteosarcoma (Osteogenic Sarcoma) 06/2014 - 07/2005
10	Breast Neoplasms (Breast Cancer) 12/2020 - 08/2011
10	Kyphosis 08/2020 - 12/2005
10	Achondroplasia 01/2020 - 10/2004
10	Aggressive Fibromatosis (Desmoid) 12/2019 - 02/2010
9	Congenital Abnormalities (Deformity) 08/2020 - 05/2008
9	Necrosis 01/2016 - 08/2005
8	Osteonecrosis (Kienbock's Disease) 04/2021 - 03/2008
7	Hemorrhage 01/2021 - 08/2004
7	Spinal Cord Compression 05/2017 - 12/2005
6	Hip Dislocation 01/2022 - 10/2006
6	Chondrosarcoma 01/2022 - 05/2012
6	Osteophyte 11/2020 - 05/2007
6	Paralysis (Palsy) 08/2020 - 09/2009
6	Sarcoma (Soft Tissue Sarcoma) 04/2019 - 03/2008
6	Arthritis (Polyarthritis) 01/2016 - 12/2006
5	Motion Sickness (Airsickness) 12/2022 - 01/2013
5	Parkinson Disease (Parkinson's Disease) 01/2021 - 04/2007
5	Joint Diseases (Joint Disease) 01/2020 - 01/2004
5	Osteolysis 12/2018 - 09/2003
5	Scoliosis 10/2016 - 10/2005
5	Musculoskeletal Diseases (Musculoskeletal Disease) 01/2014 - 07/2012
4	Cysts 01/2021 - 11/2017
4	Ependymoma 01/2021 - 03/2007
4	Intervertebral Disc Displacement (Herniated Disc) 02/2020 - 07/2006
4	Pneumonia (Pneumonitis) 07/2017 - 03/2012
4	Pathologic Constriction (Stenosis) 01/2017 - 08/2012
4	Developmental Dysplasia of the Hip 09/2013 - 09/2005
4	Margins of Excision 04/2013 - 11/2010
3	Heterotopic Ossification (Ectopic Ossification) 01/2021 - 01/2013

Drug/Important Bio-Agent (IBA)

36	Methotrexate (Mexate)FDA LinkGeneric 07/2023 - 09/2009
20	Hyaluronic Acid (Hyaluronan)IBA 01/2020 - 08/2003
18	Proteins (Proteins, Gene)FDA Link 12/2020 - 07/2002
15	tocilizumab (atlizumab)FDA Link 08/2021 - 01/2009
14	Adalimumab (Humira)FDA Link 02/2022 - 08/2012
14	Abatacept (Orencia)FDA Link 11/2020 - 09/2013
11	CateninsIBA 01/2022 - 01/2014
10	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2021 - 05/2005
9	Certolizumab Pegol FDA Link 03/2020 - 07/2014
9	Meloxicam (Mobic)FDA LinkGeneric 12/2019 - 03/2006
8	C-Reactive ProteinIBA 05/2022 - 08/2009
8	Type 3 Fibroblast Growth Factor Receptor (Fibroblast Growth Factor Receptor 3)IBA 01/2020 - 01/2013
8	Etanercept (Enbrel)FDA Link 09/2014 - 05/2009
7	Member 1 Subfamily B ATP Binding Cassette TransporterIBA 04/2023 - 01/2012
7	Cyclooxygenase 2 Inhibitors (COX-2 Inhibitors)IBA 08/2017 - 03/2006
6	Meclizine (Meclozine)FDA LinkGeneric 12/2022 - 01/2013
6	iguratimodIBA 01/2021 - 05/2013
6	Antirheumatic Agents (DMARD)IBA 01/2021 - 09/2009
6	Denosumab FDA Link 08/2020 - 06/2016
6	Matrix Metalloproteinases (MMPs)IBA 01/2020 - 01/2004
6	HymecromoneIBA 01/2020 - 01/2012
6	Cyclooxygenase 2 (Cyclooxygenase-2)IBA 05/2014 - 01/2005
6	Infliximab (Remicade)FDA Link 06/2012 - 01/2005
5	CytokinesIBA 01/2024 - 01/2004
5	GLPG0634IBA 07/2023 - 01/2022
5	Tumor Necrosis Factor InhibitorsIBA 10/2019 - 03/2015
5	golimumab FDA Link 09/2018 - 06/2012
5	Keratan SulfateIBA 04/2015 - 04/2010
4	Zonisamide (Zonegran)FDA LinkGeneric 01/2021 - 01/2015
4	Peptides (Polypeptides)IBA 12/2020 - 01/2013
4	Biomarkers (Surrogate Marker)IBA 01/2020 - 06/2003
4	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA 01/2019 - 02/2012
4	Glial Cell Line-Derived Neurotrophic Factor (GDNF)IBA 10/2016 - 07/2002
4	Monoclonal AntibodiesIBA 06/2016 - 12/2010
4	Messenger RNA (mRNA)IBA 01/2016 - 01/2004
4	Collagen Type II (Type II Collagen)IBA 06/2013 - 07/2004
3	GlucocorticoidsIBA 05/2022 - 05/2014
3	GadoliniumIBA 01/2021 - 01/2018
3	Metformin (Glucophage)FDA LinkGeneric 12/2020 - 09/2015
3	Digoxin (Digitek)FDA LinkGeneric 12/2020 - 01/2013

Therapy/Procedure

47	Therapeutics 01/2024 - 01/2005
20	Osteotomy 01/2022 - 01/2005
18	Laminoplasty 01/2021 - 10/2004
17	Hip Replacement Arthroplasty (Total Hip Replacement) 01/2022 - 09/2003
16	Decompression 02/2020 - 08/2004
13	Operative Surgical Procedures 01/2021 - 07/2006
12	Laminectomy 03/2018 - 12/2005
9	Drug Therapy (Chemotherapy) 07/2020 - 11/2008
9	Conservative Treatment 01/2019 - 12/2005
8	Activities of Daily Living (ADL) 01/2020 - 02/2005
7	Radiotherapy 12/2016 - 07/2009
6	Pedicle Screws 08/2020 - 05/2008
6	Traction 05/2017 - 09/2005
5	Knee Replacement Arthroplasty (Total Knee Replacement) 05/2022 - 07/2010
5	Operative Time 07/2020 - 08/2004
5	Nursing Care 01/2014 - 07/2012
4	Biological Therapy 10/2019 - 06/2012
4	Spinal Fusion (Spondylosyndesis) 12/2018 - 01/2013
3	Arthroplasty 05/2021 - 06/2012